Avoid or Use Alternate Drug. The recipient will receive more details and instructions to access this offer. Use Caution/Monitor. ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. If dose exceeds 20mg/kg it should be rounded down to 20mg/kg OR administration of the total dose has to be split and given 7 days apart. Copyright 1993-2021 iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Administer Feraheme as an intravenous infusion in 50-200 mL 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP over at least 15 minutes. Minor (1)iron sucrose, captopril. Use Caution/Monitor. Minor/Significance Unknown.iron sucrose increases levels of calcium chloride by enhancing GI absorption. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. Copyright 1993-2021 Applies only to oral form of both agents. VENOFER at IV doses up to 15 mg iron/kg/dose [about 10 times the maximum recommended human dose for a 70 kg person] given three times a week was found to have no effect on fertility . Here are the steps to follow for using this drug dosage calculator: First, enter the value of your Weight and choose the unit of measurement from the drop-down menu. Minor (1)iron sucrose decreases levels of manganese by inhibition of GI absorption. Separate dosing of tetracyclines from these products. Applies only to oral form of both agents. * Adapted from the KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. 2010niferex-hytinic-polysaccharide-iron-342160Drugs, You are being redirected to
2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Modify Therapy/Monitor Closely. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Your list will be saved and can be edited at any time. *Repeat dose if iron deficiency anemia reoccurs. Recommended dosage for patients weighing less than 50kg (110lb): Give Injectafer in vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Steps on how to print your input & results: 1. Our dosage calculator can help you with this as well. In post-marketing safety studies of Venofer in 1,051 patients with HDD-CKD, adverse reactions reported by >1% were cardiac failure congestive, sepsis and dysgeusia.
Formula for calculating the required dose of iron sucrose INDICATIONS AND USAGE: Intravenous or intramuscular injections of INFeD are indicated for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible.
Parenteral iron dose - UpToDate Patients with a history of drug allergy or multiple drug allergies may be at increased risk of anaphylactic-type reactions to INFeD. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hemoglobin conc. iron sucrose increases levels of calcium acetate by enhancing GI absorption. iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. Each mL contains 20 mg of elemental iron. Use Caution/Monitor. sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Am J Kid Dis 2001; 38 988991. This drug is available at a middle level co-pay. It varies from increases in dietary intake of iron (usually for prophylaxis purposes) to oral, intramuscular or intravenous therapy. informational and educational purposes only. Avoid or Use Alternate Drug. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. DOSAGE AND ADMINISTRATION: The recommended dose of Feraheme is an initial 510 mg dose followed by a second 510 mg dose 3 to 8 days later. calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Use Caution/Monitor. Applies only to oral form of both agents.
Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. Avoid or Use Alternate Drug. Applies only to oral form of both agents. In key trials, ferric carboxymaltose increased Hb levels and replenished iron stores as effectively as IV iron sucrose . LBW = Lean body weight in kg.
FERAHEME vs Venofer (iron sucrose) - Feraheme HOW TO USE: This medication is given by injection into a vein as directed by your doctor. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. Hemoglobin can be input in g/dL, g/L or mmol/L and refers to the amount of hemoglobin in the red blood cells. Dose administration to an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. Minor/Significance Unknown. Avoid or Use Alternate Drug. )If you are using this medication at home, learn all preparation and usage instructions from your health care professional. This site complies with the HONcode standard for trust- worthy health information: verify here. 4) Gozzard D. (2011) When is high-dose intravenous iron repletion needed? Human studies not conducted. Applies only to oral form of both agents. Fulminant symptoms include confusion, sensation of passing out, paleness. Where C is the concentration of the iron product: Please note that the calculations above are for information purposes only and the individual dose needs to be established by taking into account the current package insert for the elemental iron product used. Use Caution/Monitor. Use Caution/Monitor. Andreas M. Ganzoni, MD, is a physician and researcher in the internal medicine department at the University of Zurich in Zurich, Switzerland.
Iron sucrose | Drugs | BNF | NICE Most Avoid or Use Alternate Drug. iron sucrose increases levels of calcium citrate by enhancing GI absorption. This site complies with the HONcode standard for trust- worthy health information: verify here. Adults and Children over 15 kg (33 lbs): Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW), Desired Hb = the target Hb in g/dl. The cost of Venofer is $145 for a dose of 300 mg and Monoferric is $274 for a dose of 500mg. Nutrition. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Deferoxamine chelates iron. In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was . Interaction only with oral iron administration. Minor/Significance Unknown. Applies only to oral form of both agents. Administer Injectafer intravenously, either as an undiluted slow intravenous push or by infusion. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time.Your dosage and length of treatment are based on your medical condition, age, and response to treatment. UpToDate. Do not administer Venofer to patients with iron overload. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. If no signs or symptoms of anaphylactic-type reactions follow the test dose, administer the full therapeutic INFeD dose. Applies only to oral form of both agents. Venofer® (iron sucrose) injection, USP is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). . The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 Hb in g/dL) x 2.145, Volume of product required in mL = Iron deficit in mg / C in mg/mL. Most reactions associated with intravenous iron preparations occur within 30 minutes of the completion of the infusion. Access your plan list on any device mobile or desktop. Each mL contains 20 mg of elemental iron. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. Intravenous therapy is usually recommended in case of contraindications to oral iron, comorbidities that prevent absorption, chronic renal impairment or iron replacement needs to be rapid. iron sucrose decreases levels of ibandronate by inhibition of GI absorption. deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Minor/Significance Unknown. Methods: We reviewed the experience of our department between January, 2011 and February, 2014 with the use of intravenous iron sucrose in children 14 years of age who failed in oral iron therapy for iron deficiency anemia (IDA). No additional iron to replenish stores. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Iron Dextran Dosing Calculator (iron deficit). ------------------------------------------------------------------------- Ferric Carboxymaltose [ Injectafer ] Elemental iron: Injectafer contains 50 mg of elemental iron - 750 mg/15 mL [package insert] Indications: Injectafer is indicated for the treatment of iron deficiency anemia in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron; who have non-dialysis dependent chronic kidney disease. Brand name: Venofer Drug class: Iron Preparations Chemical name: iron saccharate CAS number: 8047-67-4 Medically reviewed by Drugs.com on Oct 25, 2022. Monitor Closely (1)rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Both the 200- and 300-mg doses of IV iron sucrose administered over 2 hours appear to be safe. IDA diagnosis is based on full blood examination and on the serum ferritin level. Use Caution/Monitor.
When administering as a slow intravenous push, give at the rate of approximately 100 mg (2 mL) per minute. 2010;18(3). Assessing new treatment options. Separate dosing of tetracyclines from these products. Venofer treatment may be repeated if necessary. IDA symptoms are often nonspecific and include tiredness, weakness, shortness of breath. Venofer is manufactured under license from Vifor (International) Inc., Switzerland. Give each dose as 750 mg for a total cumulative dose not to exceed 1500 mg of iron per course. Hypotension following administration of Venofer may be related to rate of administration and/or total dose delivered. Applies only to oral form of both agents. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: vitamin products, other iron-containing products. iron sucrose, captopril.
Iron Deficiency in Heart Failure - Home - American College of Cardiology Monitor Closely (1)aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Total dose iron infusion: safety and efficacy in predialysis patients. FERAHEME was non-inferior to Venofer (iron sucrose) in mean Hgb rise from baseline 2,5. 4. Venofer and the Venofer logo are registered trademarks of Vifor (International) Inc., Switzerland. Minor/Significance Unknown. Calculosaurus | Medical calculators for obstetrics and gynaecology Use the menu to browse through our clinical calculators. Deferasirox chelates iron. Then you can click on the Print button to open a PDF in a separate window with the inputs and results. Applies only to oral form of both agents. In the text below the tool there is more information on how the iron deficit is calculated.
PDF Iron dosing and administration in adults backgrounder For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every two weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Elemental iron product this is a choice between three iron supplement products: Iron dextran 50 mg/mL, Iron sucrose 20 mg/mL and Ferric gluconate 12.5 mg/mL. The above information is provided for general Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Anemias. Avoid or Use Alternate Drug. Minor/Significance Unknown. IV iron sucrose (Venofer) given as divided dosages, and low molecular weight iron dextran (CosmoFer) this can be given as divided dose or as a total dose infusion . 3) Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. (1988) Clinical use of the total dose intravenous infusion of iron dextran. Contact the applicable plan Applies only to oral form of both agents. Last updated on Jun 1, 2022. Interaction only with oral iron administration. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium.
PDF Treatment Guideline - Gloucestershire Royal Hospital Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Do Not Copy, Distribute or otherwise Disseminate without express permission. Venofer (Iron Sucrose Injection) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. iron sucrose increases levels of calcium gluconate by enhancing GI absorption.
Venofer (iron sucrose) dose, indications, adverse effects - PDR The weight of the patient is taken into account in order to estimate iron stores, while haemoglobin is required as both current measured and target. Minor (2)calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Ferrlecit has been administered at sequential dialysis sessions by infusion or by slow intravenous injection during the dialysis session itself. Use Caution/Monitor. Pediatric Patients: The most common adverse reactions (2%) are headache, respiratory tract viral infection, peritonitis, vomiting, pyrexia, dizziness, cough, nausea, arteriovenous fistula thrombosis, hypotension and hypertension. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Monitor Closely (1)cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Included in the iron dextran package insert. Sodium ferric gluconate (Ferrlecit) 62.5 mg . The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs.
Venofer Injection Prescribing Information - Drugs.com This drug is available at a higher level co-pay. * Calculators are available in UpToDate to determine ideal body weight and lean body weight. This drug is available at the lowest co-pay. Case G. Maintaining iron balance with total-dose infusion of intravenous iron dextran. however iron sucrose requires multiple small intermittent doses over days to weeks. Modify Therapy/Monitor Closely. Have resuscitation equipment and personnel trained in the detection and treatment of anaphylactic-type reactions readily available during INFeD administration. Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)- . For adult CKD patients on ESA therapy who are not receiving iron supplementation, the guideline suggests a trial of IV iron (or in NDD-CKD patients, alternatively, a 1- to 3-month trial of oral iron therapy) if: CKD=chronic kidney disease ESA=erythropoietin-stimulating agent Hb=hemoglobin IV=intravenous RBC=red blood cell WBC=white blood cell. Applies only to oral form of both agents. omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. 200-800 mg/kg (2-8 mL/kg) every 3-4 weeks. We have found the lower dose to be better tolerated in the second half of gestation. During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. Dosage form: injection, solution Use Caution/Monitor. commonly, these are "preferred" (on formulary) brand drugs. Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. Modify Therapy/Monitor Closely. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=abacb7fa-2fc2-471e-9200-944eeac8ca2a. Finally, a 400-mg dose by 2-hour infusion was examined in 35 patients, but 2 patients experienced such symptoms as hypotension, nausea, and lower back pain. Drug Des Devel Ther; 5: 5160. Medically reviewed by Drugs.com. Oral and parenteral products - see background option for oral products. Use alternatives if available.
Iron Sucrose Protocol - Cmqcc Get in touch with MDApp by using the following contact details: 2017 - 2023 MDApp.
Iron Injection Administration | INJECTAFER HCP The dosage of iron sucrose is expressed in mg of elemental iron. Kidney Int. . Only administer Feraheme as an intravenous infusion over at least 15 minutes and only when personnel and therapies are immediately available for the treatment of anaphylaxis and other hypersensitivity reactions. 2010;18(3). Ferumoxytol [ Feraheme ] Elemental iron: 510 mg/17 mL (17 mL) 30 mg/mL [package insert] - Boxed warning REVIEW INSERT. By taking into account the case of a patient weighing 78 kg (172 lbs) and having a hemoglobin level of 11 g/dL (110 g/L or 6.83 mmol/L). Avoid or Use Alternate Drug. Maximum recommended single dose: 300 mg (See Prescriber's Orders).
Aranesp (darbepoetin alfa) | Dosing Considerations Serious - Use Alternative (1)iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Serious hypersensitivity reactions, including anaphylactic-type reactions, some of which have been life-threatening and fatal, have been reported in patients receiving Venofer. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Treatment of iron deficiency anemia associated with gastrointestinal tract diseases, Diagnosis and management of iron deficiency anaemia: a clinical update. Allow at least 30 minutes between administration of Feraheme and administration of other medications that could potentially cause serious hypersensitivity reactions and/or hypotension, such as chemotherapeutic agents or monoclonal antibodies. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Use Caution/Monitor. Avoid or Use Alternate Drug. These can be input in g/dL, g/L or mmol/L. Serum iron, total iron binding capacity (TIBC) and percent saturation of transferrin are other important tests for detecting and monitoring the iron deficient state. Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia. I. Ren Fail. It is important to note that the above calculations merely provide estimates and that individual dosage should be established by a medical professional based on the current package insert for the elemental iron product used. FOR PATIENTS WEIGHING LESS THAN 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intravenous infusion 20 minutes . Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Pediatric Patients (2 Years of Age and Older). .
Iron Deficiency Calculator - MDApp Observed Hb = the patients current hemoglobin in g/dl. Multiple placebo-controlled, randomized clinical trials have been conducted with IV iron in patients with New York Heart Association class II-III heart failure with an ejection fraction 45% who met criteria . Applies only to oral form of both agents. elemental iron (mg/ml) in the product being used: Where C=
Venofer (iron sucrose) dosing, indications, interactions, adverse Use Caution/Monitor.
Calculosaurus | Ferinject dose calculator In case a pediatric patient with a weight below 35 kg is assessed, iron stores are calculated as 15 mg iron for each kg. Learn how to store and discard medical supplies safely. Initial symptoms may include hypotension, syncope, unresponsiveness, cardiac/cardiorespiratory arrest. The elemental iron product used is Iron sucrose 20 mg/mL. This calculator will help pinpoint potential causes of anemia based on Only administer Venofer when personnel and therapies are immediately available for the treatment of serious hypersensitivity reactions. This health tool computes the required parenteral iron replacement dose for the iron deficit extracted from the patient weight and hemoglobin level from complete blood count test. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Either increases effects of the other by pharmacodynamic synergism. calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling [16.2].) Iron deficiency anemia is the type of anemia caused by iron depletion. You may need extra iron because of blood loss during kidney dialysis. By entering this website, you acknowledge that you are a licensed healthcare professional practicing in the United States. Adult Dosage and Administration: The recommended dosage of Ferrlecit for the repletion treatment of iron deficiency in hemodialysis patients is 10 mL of Ferrlecit (125 mg of elemental iron). All Rights Reserved. If either is present, do not use the liquid. Iron Product. Applies only to oral form of both agents. The iron deficit estimation is based on the Ganzoni formula: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. official version of the modified score here. Minor/Significance Unknown. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Avoid or Use Alternate Drug.
PDF PRODUCT MONOGRAPH - pdf.hres.ca A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. trientine, iron sucrose. 2022 American Regent, Inc.PP-VE-US-0016 (v6.0)1/2022. The factor 2.4 comes about from the calculation that the total iron content of hemoglobin is 0.34%, the blood volume accounts for 7% . Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. Clinical use of the total dose intravenous infusion of iron dextran. Dosing Administration & Considerations . Applies only to oral form of both agents. Applies only to oral form of both agents. Can't find what you need? SIDE EFFECTS: Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur.